We include products we think are useful for our readers. If you buy through links on this page, we may earn a small commission Here’s our process.
Medical News Today only shows you brands and products that we stand behind. Honey Glass
Some of the most potent oils contain up to 12,000 milligrams (mg) of cannabidiol (CBD) per 30 milliliters (mL). We look at nine of the best potent options and provide hands-on reviews for oils from FAB CBD and Nuleaf Naturals.
Is CBD legal?The 2018 Farm Bill removed hemp from the legal definition of marijuana in the Controlled Substances Act. This made some hemp-derived CBD products with less than 0.3% THC federally legal. However, CBD products containing more than 0.3% THC still fall under the legal definition of marijuana, making them federally illegal but legal under some state laws. Be sure to check state laws, especially when traveling. Also, keep in mind that the FDA has not approved nonprescription CBD products, and some products may be inaccurately labeled.
Medical News Today chooses strong CBD oils that meet the following criteria:
Medical News Today follows a strict product selection and vetting process. Learn more here.
Below are some examples of high-strength CBD oils and tinctures.
Please note that this article’s writer has not tried these products, and all the information presented is research-based. All the products tested below were tried by Healthline writers or editors, who received the oils for free. All opinions are their own.
Use code “healthline20” for 20% off.
Zatural Broad Spectrum CBD Oil Drops contain hemp seed oil with no additives or fillers. The oil also contains terpenes, flavonoids, and phytocannabinoids.
This product is available in 1, 2, and 4 fl oz bottles, containing 300–12,000 mg of CBD.
The 12,000 mg option provides a CBD dosage of 100 mg per serving, making it one of the strongest CBD oils in this article.
However, the higher the potency, the more expensive each bottle gets, with this 12,000 mg option costing $360.
People can subscribe and save 20% each order. Zatural offers automatic deliveries every 1–4 months.
cbdMD’s CBD Oil Tincture Drops contain 7,500 mg of broad-spectrum CBD per 1 fl oz bottle. The oil provides 250 mg of CBD per serving, the strongest dose in this article.
It contains additional cannabinoids, including cannabinol (CBN) and cannabigerol (CBG). It is also made with MCT oil.
This CBD oil is vegan and free from THC and gluten. It comes in natural, mint, orange, or berry flavor.
Read our cbdMD review here.
cbdMD states people can opt for automatic deliveries every 14, 30, 60, or 90 days and benefit from:
People can skip, pause, or cancel deliveries at any time.
Use code HEALTHLINE for 20% off all orders.
Spruce’s 2,400 mg full-spectrum CBD Oil delivers 80 mg of full-spectrum CBD per 1 milliliter (mL) dose, equivalent to a full dropper.
The oil is organic and contains no added flavorings. People can choose from two carrier oils: hemp seed oil and MCT oil. The product is also vegan and gluten-free.
This product contains 0.3% THC. The company states that a person taking it might test positive for cannabis, which is unsuitable for people undergoing drug testing.
Spruce Labs offers 15% off and free shipping if people sign up for automatic deliveries. However, the company does not state how frequent these deliveries will be on the product page.
Use code “MNT” for 15% off and free shipping.
Use code “HEALTHLINE” for 20% off.
NuLeaf Naturals offers a full-spectrum CBD oil available in a range of bottle sizes and dosages, from 300–6,000 mg.
The company suggests that people start by using 30 mg or 10 drops each day in two separate doses. They may then increase the dose slowly if needed.
NuLeaf Naturals use full-spectrum CBD and organic virgin hemp seed oil to produce CBD oil products.
The product is unflavored and contains terpenes.
The more potent the product, the more expensive it is, and the strongest option costs $269. People can also buy a single bottle or buy packs of 3 or 6 bottles.
NuLeaf offers 20% off each order if a person subscribes to automatic delivery every 2–12 weeks.
“I tried this oil to relieve muscle pain. I recently had chronic pain in my left shoulder stemming from a nagging rotator cuff injury sustained while surfing. I was in pain every day and it affected my quality of life. The pain altered my sleep for the worse, and I couldn’t swim or surf — my daily form of exercise.
“No amount of physical therapy or prescription drugs were providing lasting relief. This CBD oil was the only thing that blocked the pain. Although it was a new type of physical therapy, proprioceptive-deep tendon reflex therapy, that cured my pain, this CBD not only relieved the pain, it helped improve my mood, which was suffering from being in constant pain.
“CBD is not a miracle cure, but it can help relax your muscles and block the pain signals. I take CBD after I surf and I’m feeling rejuvenated.
“I’d recommend it to Medical News Today readers as it’s a product from a trusted brand, and I found it effective for easing chronic muscle pain. I think it would best suit an experienced CBD user who needs strong relief, but not a maximum strength dose.” — Nick Balboa, Healthline writer
“I tried this oil to relieve muscle pain. I recently had chronic pain in my left shoulder stemming from a nagging rotator cuff injury sustained while surfing. I was in pain every day and it affected my quality of life. The pain altered my sleep for the worse, and I couldn’t swim or surf — my daily form of exercise.
“No amount of physical therapy or prescription drugs were providing lasting relief. This CBD oil was the only thing that blocked the pain. Although it was a new type of physical therapy, proprioceptive-deep tendon reflex therapy, that cured my pain, this CBD not only relieved the pain, it helped improve my mood, which was suffering from being in constant pain.
“CBD is not a miracle cure, but it can help relax your muscles and block the pain signals. I take CBD after I surf and I’m feeling rejuvenated.
“I’d recommend it to Medical News Today readers as it’s a product from a trusted brand, and I found it effective for easing chronic muscle pain. I think it would best suit an experienced CBD user who needs strong relief, but not a maximum strength dose.” — Nick Balboa, Healthline writer
Use code “Healthline10” for 10% off your first order. One-time use only.
This full-spectrum oil from Lazarus Naturals is available unflavored or in chocolate mint or strawberry lemonade flavors.
It is available in sizes of 30 mL or 120 mL. A 30 mL bottle contains 1,500 mg of CBD, while a 120 mL bottle contains 6,000 mg of CBD. Each serving of 0.25 mL contains 50 mg of CBD.
This product has USDA Organic and Kosher certifications. Ingredients include organic coconut oil, organic hempseed oil, organic hemp extract, and flavorings.
Lazarus Naturals recommend people start with a 0.25 mL dose, wait for 2 hours, and repeat as necessary.
Read our Lazarus Naturals review.
Lazarus Naturals does not offer a subscribe and save option.
However, people can checkout with Sezzle and pay off the order in several interest-free payments. People must have a minimum order of $25 to use this option.
The 30 mL or 100 mL bottle each contains 60 mg of CBD per 1 mL, making it the highest concentration per mL of CBD the company provides.
Charlotte’s Web says this product suits those who already take CBD and want to steadily increase their CBD dosage in their supplement routine.
This full-spectrum product has a variety of phytocannabinoids, terpenes, and flavonoids. It comes in orange blossom, lemon twist, and mint chocolate flavors.
The company states that the CO2 extraction process it uses is environmentally friendly. It uses carbon dioxide, which the manufacturer claims is safe and clean and has no negative environmental impact.
Read our review of Charlotte’s Web.
CBD.co does not currently offer a subscribe and save option for this product.
However, people with qualifying orders can checkout with Klarna or Sezzle, allowing them to pay off the product in several interest-free payments.
Use code “HEALTHLINE” for 25% off.
This full-spectrum CBD oil is available in doses of 25 or 50 mg per 1 mL. Each 1 mL serving also contains either 0.5 or 1 mg of THC.
This oil is only available unflavored. It contains organic hemp flower extract and organic MCT coconut oil. According to the company, it has a smooth and mild flavor.
Cornbread says that only using cannabis flowers increases the amount of cannabinoids and reduces the amount of chlorophyll in the product. The company states that other manufacturers may use stems, leaves, and stalks, which may reduce the quality of the oil.
Read our review of Cornbread.
Cornbread offers free shipping and 20% off each order if a person subscribes for automatic delivery every 30, 45, or 60 days.
Use code “health20” for 20% off.
This Medterra oil contains CBD isolate and MCT oil. CBD isolate means that the product does not contain any THC. Each 1 mL serving provides 16, 33, or 100 mg of CBD, depending on the strength a person purchases.
Medterra states that this oil may be a suitable option for those who undergo drug testing, as CBD isolate does not contain THC.
It is non-GMO and made in the United States.
Medterra recommends using one dropper one or more times per day.
Medterra offers 30% off each order and free shipping if a person subscribes to automatic deliveries every one or two months.
Use code “HEALTHLINE” for 20% off your first purchase
SHOP NOW AT FAB CBD
FAB CBD pair CBD with cannabigerol (CBG) in this unique and potent oil. There is 2,400 mg of full-spectrum CBD and CBG in each 30 mL bottle.
CBG is a minor cannabinoid that is not usually present in as high amounts as CBD. However, FAB CBD claims to include equal amounts of each in this oil. CBG may provide anti-inflammatory benefits.
FAB CBD includes CBG to enhance the effect of the oil, stating that it boasts a powerful entourage effect. This refers to the idea that the components of CBD are more effective together than in isolation.
FAB CBD states its oil is pesticide free and uses organic and non-GMO ingredients.
Learn more about the differences between CBD and CBG.
FAB CBD offers 20% off each order if a person subscribes to automatic deliveries every 2–10 weeks. People can modify and cancel their deliveries at any time. The brand also offers free shipping on orders over $99 and a 30-day money-back guarantee.
“I tested this oil on different days over the course of two months. It has a very neutral and lightly minty taste.
“One response that I wasn’t expecting, and I can only say coincided with taking this oil, was on two separate instances I seemed to be sad more readily and prone to cry in the face of low-level stressors. I can’t say this oil caused me to cry more easily, but it seemed of note as these dips in sadness happened 1–2 hours after taking a 0.5 or 1 mL dropper of the oil. That’s an amount I have taken of other CBD oils of varying strengths (though none emphasized CBG). Some research suggests that depressive symptoms can be exacerbated by cannabinoids, but I can’t say conclusively if CBG caused this reaction in me.
“I found unlike some other CBD oils, this one would be better if I was ready to go to sleep pretty much right away since when it did take effect it made me quite drowsy. However, I didn’t necessarily stay asleep through the night. I’d wake up if I needed to go the bathroom, which I prefer over being totally zonked out.
“I would recommend this product if you’re comfortable with experiencing multiple cannabinoids. It is a 1:1 combination of CBD and CBG, which is a minor cannabinoid in the cannabis plant that wouldn’t typically be present in the same amount as CBD.
“That said, I wouldn’t recommend this to anyone who is unfamiliar with and nervous or uncertain about CBD.” — Candice Abellon, Healthline editor
“I tested this oil on different days over the course of two months. It has a very neutral and lightly minty taste.
“One response that I wasn’t expecting, and I can only say coincided with taking this oil, was on two separate instances I seemed to be sad more readily and prone to cry in the face of low-level stressors. I can’t say this oil caused me to cry more easily, but it seemed of note as these dips in sadness happened 1–2 hours after taking a 0.5 or 1 mL dropper of the oil. That’s an amount I have taken of other CBD oils of varying strengths (though none emphasized CBG). Some research suggests that depressive symptoms can be exacerbated by cannabinoids, but I can’t say conclusively if CBG caused this reaction in me.
“I found unlike some other CBD oils, this one would be better if I was ready to go to sleep pretty much right away since when it did take effect it made me quite drowsy. However, I didn’t necessarily stay asleep through the night. I’d wake up if I needed to go the bathroom, which I prefer over being totally zonked out.
“I would recommend this product if you’re comfortable with experiencing multiple cannabinoids. It is a 1:1 combination of CBD and CBG, which is a minor cannabinoid in the cannabis plant that wouldn’t typically be present in the same amount as CBD.
“That said, I wouldn’t recommend this to anyone who is unfamiliar with and nervous or uncertain about CBD.” — Candice Abellon, Healthline editor
The table below provides a quick comparison of the strongest CBD oils in this article:
A person interested in trying CBD oil should research different products to find one that is safe and reliable. Customer reviews from third-party sites, such as the Better Business Bureau and Trustpilot, are useful tools when researching brands.
Individuals may want to review each product’s ingredient list and concentration levels. They might want to know if the product is lab-grade and third-party tested.
A person using CBD for the first time may find a product with a lower dosage more suitable. They can then gradually increase the dosage as desired.
Read our complete CBD buyer’s guide or learn how to buy the best CBD oil.
According to research, CBD can negatively interact with medications, such as anticonvulsants, including diazepam, lamotrigine, and phenytoin.
People should also not use CBD alongside sedative drugs, such as barbiturates, and narcotics, such as codeine and morphine. Anybody taking medication should speak with a qualified healthcare professional prior to taking CBD.
CBD can make people drowsy, so people should avoid driving and handling heavy machinery when taking this product.
A person taking CBD for the first time should avoid strong CBD. It is better to start with a lower dose and increase the dosage slowly.
A person should always speak with a healthcare professional before using CBD products.
While there is a wealth of research regarding the effects of cannabis and THC, few high quality human trials are investigating CBD alone.
It is difficult for experts to predict precisely how differences in strength affect CBD’s effectiveness.
Based on the findings of a 2020 review, CBD appears relatively safe at various doses. However, the authors did not pinpoint a specific dose or range of doses they believed would benefit everyone.
Most of the studies included in this review evaluated daily doses of 300–600 mg of CBD, but a few studies reported using doses as high as 2,000 mg per day.
Everyone responds differently to CBD, so it is best for people using CBD for the first time to start at a lower dose.
Purchasing a higher CBD concentration product may be more cost-effective and convenient for some people.
For example, someone who uses 300 mg of CBD for chronic pain or anxiety would use 12 full droppers of 25 mg of CBD oil. They could get a similar 300 mg dose by using only one and a half droppers of 2,000 mg CBD oil.
However, stronger products may provide more CBD per unit but may lead to inaccurate dosing.
Learn more about CBD dosage.
CBD does not appear to cause any significant side effects, even at doses above 150 mg per kilogram (kg) of body weight.
However, the Food and Drug Administration (FDA) warns that using CBD products may produce the following adverse effects:
The FDA has approved only one CBD product, called Epidiolex, which is for severe forms of childhood epilepsy. The FDA does not regulate any other CBD products.
Learn more about the side effects of CBD.
People should avoid purchasing products from companies that have inaccurate labeling. The FDA has a database of CBD companies to which it has issued warnings, as the content did not match the amount of CBD on the product’s labels.
In a recent study, researchers found that nearly half of the 80 CBD products it looked at that were available for sale in central Kentucky had inaccurate label information.
However, most reputable CBD manufacturers will provide third-party lab results to their customers.
People should always use caution when shopping for CBD, especially high-potency products. High-potency CBD products can be inaccurately labeled. Some products may not even contain CBD.
Additionally, some CBD products may contain enough THC to produce a positive result in a drug test.
Learn more about THC and drug tests.
A person should always speak with a healthcare professional before trying any supplement, including CBD oil, especially if they are currently taking medication. If they are considering taking CBD for a particular health problem, such as sleep issues, anxiety, or pain, they should speak with a doctor to make sure it is a suitable supplement to try.
If they experience side effects after taking CBD, they should stop using it and contact a doctor.
Below are some of the most commonly asked questions about strong CBD oils.
Full-spectrum CBD oil is likely to be the most potent type as it contains the full range of cannabinoids.
One of the strongest levels of CBD on the market in the U.S. is 12,000 mg per 30 mL. This features in a Zatural CBD oil.
Yes, people can buy 5,000 mg CBD oil in the U.S. Level Select and CBDistillery sell 5,000 mg CBD oils.
1,000 mg CBD is a moderate to high dose of CBD.
40% CBD oil means that 40% of a product’s total volume is CBD. The remaining 60% can comprise other cannabinoids, terpenes, carrier oils, and other ingredients.
Yes, 5,000 mg CBD is a strong dose. People should take this dose as the manufacturer directs. It is unlikely to be suitable for those new to using CBD.
Yes, 3,000 mg CBD is a strong dose. It is unlikely to be suitable for people new to using CBD.
CBD oil is a popular product with many potential benefits. However, more high quality, controlled trials are necessary to verify the medical applications of CBD.
People who currently use CBD products but feel they may benefit from stronger alternatives can use this article for guidance. Those who have never used CBD but are interested in trying it should start with a low dose and gradually work up to more potent products.
People should also discuss CBD with a doctor, as it might interact with medications and supplements.
Last medically reviewed on October 9, 2023
People use CBD oil for many reasons, including pain, depression, and nausea and vomiting induced by chemotherapy. Learn more here.
Is CBD oil good for skin? Read on to find out whether it can benefit skin, what skin conditions it may help, how to use it, and how to choose CBD oil…
Full-spectrum CBD includes all compounds in the cannabis plant and may help with anxiety and pain. Learn more about the best full-spectrum CBD…
Aromatherapy Dropper Bottles Pure CBD is also known as CBD isolate and does not contain tetrahydrocannabinol (THC). Learn about its benefits and the best pure CBD products here.